Systems Microbiology

The research mainly focuses on:

  • Extremophilic microorganisms to optimize production of industrially and medically important exopolysaccharides and enzymes via systems biology approaches.
  • Chromohalobacter salexigens as a model organism for halophilic bacteria.
  • Saccharomyces cerevisiae (Baker’s yeast) as a model organism for eukaryotic cells.

Research Topics are:

  • Purification, characterization and recombinant production of levansucrase enzyme by Halomonas smyrnensis AAD6T
  • Investigation of the fructose uptake system in Halomonas smyrnensis AAD6T to design strategies for enhanced levan biosynthesis
  • Comparative genomics of halophilic bacteria
  • Brevibacillus thermoruber as a microbial cell factory for exopolysaccharide production (in collaboration with Bulgaria Academy of Sciences)
  • Reconstruction and analysis of comprehensive protein-protein and signal transduction networks in Saccharomyces cerevisiae and human
  • Development of novel network metrics for topological analysis of complex biological networks
  • Whole genome sequencing and genome annotation of levan producing Halomonas smyrnensisAAD6T
  • Bioinformatics based metabolic network reconstruction of levan producing Halomonas smyrnensis AAD6T
  • Genome-scale reconstruction and analysis of metabolic network for halophilic extremophile,Chromohalobacter salexigens DSM 3043
  • System-based network approach to develop hypotheses for ethanol tolerant yeast strains (in collaboration with Boğaziçi University Department of Chemical Engineering)

This page updated by System Bioengineering on 12.01.2015 09:25:16